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In head-to-head comparisons across trials, retatrutide consistently produces greater weight reduction than both semaglutide and tirzepatide at equivalent timepoints

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Participants who had not lost at least 5% of their starting body weight by week 12 rarely achieved robust results by week 48

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Clinical trial data shows retatrutide produces greater weight loss than either semaglutide or tirzepatide at their respective maximum doses