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Abbreviations: DLT, dose-limiting toxicity

A once-daily oral PCSK9 inhibitor with antibody-like efficacy could transform treatment adherence and accessibility Safety profile Adverse events and discontinuations were low and comparable across treatment arms (~24%) Durability matters LDL-C reductions sustained up to 52 weeks in CORALreef analyses, reinforcing long-term potential Take-home message Enlicitide may redefine oral lipid-lowering strategies for patients not at goal despite statins Whats your view: practice-changing innovation or still too early

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