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To assess the efficacy of combination treatment, tumour-bearing mice were treated as above with 5FU + metformin and CC3-quantified, showing an increase in average cell death per tumour per mouse with combination treatment (Extended Data Fig

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Female C57BL/6J mice (10 weeks old) were fasted for 4 h and infected orally with 1 10 10 c.f.u.s in 200 l PBS

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