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If a sufficient reduction in HbA 1c levels is not achieved with metformin, treatment is typically escalated by reinforcing the importance of diet and exercise to induce weight loss, and adding a second non-insulin pharmacological treatment (Step 2a)

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Treating diabetes and obesity to improve health outcomes for Americans has become a priority for this administration

Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats

Think of GLP-1s as a potential add-on, especially if you have overweight or obesity, metabolic syndrome, or if cravings tend to cluster around mealtimes or evenings