In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition
Predicted protein structures by AlphaFold and homology modeling must be used for comparison of family members with unknown structures
Alcoholic Liver Disease (ALD) is the result of the way our body treats alcohol in the liver where alcohol metabolic products lead to the formation of Reactive Oxygen Species (ROS) that harm cells through interacting with fats, proteins, and DNA
The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
In conclusion, our research offers in vitro and in vivo evidence to unravel the complexities and implications of IL-33 in EMs, shedding light on its potential interaction with the Wnt/-catenin pathway
