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Systematic integration of quantitative and qualitative information into the framework of an adverse outcome pathway revealed the causal involvement of oxidative stress in liver pathologies such as drug-induced liver injury, alcoholic liver disease, cholestatic liver injury, and nonalcoholic fatty liver disease (Kuijper et al

(IGPP00055) and National Institute of Diabetes and Digestive and Kidney Diseases grants to X.Z

Insulin function is abnormal due to impaired binding of insulin to the receptor is called type A IR syndrome (TAIR) [38]

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These pathways work together to mediate the inhibition of ferroptosis by FSP1 (Fig