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One of these studies also failed to identify any change in anxiety-like behavior 162 , while two further studies employing exendin-4 observed an anxiogenic effect following acute administration 158,169

In line with this vital role in mitochondrial defense, Gpx4 null mice die during early embryonic development, while Gpx4 + / - cells are sensitive to oxidative stress triggers (Legault et al., 2000

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