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While the mid regions of both peptides interact with the top of TM1/ECD stalk, the ECD, ECL1 and the top of TM2, exendin-4 exhibits more persistent interactions in the simulations, particularly with the TM1/stalk and ECD (Supplemental Tables 1 and 3)

The identified lipids spanned five major categories: fatty acyls, glycerolipids (GLs), glycerophospholipids (GPLs), sphingolipids (SPLs), and sterol lipids (STLs)

Although we initially attributed this to impaired beta cell function, as reported in Gcgr / mice [21], normalisation to protein content largely eliminated this effect