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2.3 Pharmacological treatments for DPN According to the relevant guidelines in China released in 2021 ( 3 Preclinical evidence of neuroprotective effects of GLP-1R agonists in DPN In patients with DM, the metabolism of glucose, lipids, proteins, and nuclear acids is largely dysregulated

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In addition, it can achieve a dual effect of "increased energy expenditure" and "reduced energy storage" by inhibiting adipocyte differentiation, promoting fat breakdown, and reducing adipose tissue accumulation