Dulaglutide outperformed insulin glargine, the active comparator, in achieving glycemic control in patients with type 2 diabetes and a mean estimated GFR (eGFR) of 38 13 mL/min per 1.73 m 2
For such molecules, oral delivery may achieve meaningful therapeutic benefit through local activity even if systemic absorption is inadequate
Evidence from Studies While some studies have shown promising results regarding glutathione's ability to lighten skin, the evidence specifically addressing lip pigmentation is still limited
Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa
But people can be super judgmental especially about taking a GLP-1 medication (but they can be super judgey about me being fat, too, so it's kind of a zero-sum game)