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The primary outcome was time to first major CVD event (ischaemic heart disease, stroke, HF or peripheral arterial disease) after starting the GLP-1RA

Compared to alternative antidiabetic regimens, GLP-1 analogs are particularly helpful in mediating weight loss in obese, diabetic patients on antidepressants, particularly in patients on selective serotonin reuptake inhibitors

Relevant hostmicrobial interactions include the expression of host genes that are involved in drug transport and metabolism, the interference with host enzymatic activity and the modulation of immune responses

Aside from serotonin, tryptophan is catabolized into several other neuroactive compounds, including the neurotoxic kynurenine (KYN) and the neuroprotective kynurenic acid (KYNA) (Figure 3)

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