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The results mirror a previous observation from our group, that hypothalamic Gipr KO appeared to sensitize DIO mice to weight loss induced by a long-acting GLP-1R agonista finding that had not been the focus of that study and remained unexplained at the time but has since also been observed in global GIPR-KO mice 7,11

Missed doses significantly impact efficacy, particularly given the medication's once-weekly dosing schedule

PlexusDx's compounded semaglutide at $189/month represents a 85% reduction compared to brand retail costs, without sacrificing pharmaceutical quality or clinical efficacy

Scarano, A

Additionally, semaglutide is not recommended in patients with severe gastroparesis, which may be relevant for Crohn's patients with motility complications