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The pharmacodynamic endpoints were change from baseline to end of treatmentdefined as 1 week after the last dosein body weight, fasting plasma glucose (FPG), and other fasting glucose metabolism parameters (insulin, C-peptide, glucagon, and pro-insulin)

It inhibits inflammatory cytokines, which helps calm the red, angry flush associated with reactive skin

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Agouti-Related Protein (AgRP) produced in the hypothalamus stimulates appetite by inhibiting the activity of melanocortins