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TMAO enhances the production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-

This depends on how severe the deficiency is, any health conditions, and how well the therapy works

It preserves lean mass better than either approach, likely due to its effects on insulin signaling and muscle protein synthesis

Moreover, the temperature of the medium cannot be so high that the stability of the particular agent being incorporated in the microspheres is adversely affected