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The activity of CPT1C is distinct from those of CPT1A and CPT1B in that it does not act on the same types of fatty acyl-CoAs that are substrates for the latter two enzymes, nor does it participate in the mobilization of fatty acids into the mitochondria

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Third , the combination lacks robust safety data from controlled trials, meaning potential synergistic effects or unexpected interactions remain inadequately characterized

Glassford et al., 2013