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Researchers have also found that GLP-1-MK-801 alters the gene expression in signaling pathways associated with both GLP-1 and MK-801, suggesting a coordinated interaction between these two receptor systems

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10.1016/j.phymed.2023.155218 107 LiuX.LuJ.LiaoY.LiuS.ChenY.HeR.et al (2019b)

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For example, mice fed a high-fat diet for 21 days have both lipid and protein compositional changes in cellular plasma membranes that result in an impaired capacity for oxidative phosphorylation, increased reactive oxygen species (ROS) production, hepatosteatosis and insulin resistance (Shama et al., 2023)