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PLoS One (2012) 7:e42504.10.1371/journal.pone.0042504 36 FryeRE

In this theory, reduced amounts of IGF-1 bioavailability would impact sebocyte proliferation via the loss of regulatory functions that IGF-1 has on 5-Reductase, while also causing impaired processing of secreted lipids in the interfollicular epidermis, which combined could result in the eventual keratinization of both the sebaceous gland and the impaired epithelial barrier of the follicular canal

However, the metabolic improvements and weight loss associated with GLP-1 therapy may indirectly affect hormonal factors that influence acne severity

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