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Read more CELIAC DISEASE AND NON-CELIAC GLUTEN SENSITIVITY (Part 3/5) The European Society for Paediatric Gastroenterology, Hepatology and Nutrition defines Celiac Disease ( CD ) as a systemic immune-mediated (i.e., autoimmune) disease caused by gluten and related prolamins in genetically susceptible individuals and is characterized by a variable combination of gluten-dependent clinical manifestations, specific CD antibodies demonstrated in analytical tests, HLA DQ2 or DQ8 haplotypes, and enteropathy, producing inflammation and destruction of the