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Analysis and identification of oxidative stress-ferroptosis related biomarkers in ischemic stroke

However, N-acetyl-p-benzoquinone imine (NAPQI) approximately 5% of a therapeutic dose is metabolized by the liver enzyme cytochrome P450 2E1 to the electrophile N-acetyl-p-benzoquinone imine (NAPQI)

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Following approaches to grade severity of the lesions done from mid luminal at the thyroid glands largest cross-sectional area compared to control and scored as follows: grade 0, 1, 2 and 3 (not significant change 80% of tissue affected respectively) (Miyata and Ose 2012)