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237,238 AGEs accumulate in peripheral nerves and interact with the receptor for AGEs (RAGE) on cell surfaces, activating intracellular signaling pathways involving NF-B
Zhao M, Zhao L, Xiong X, He Y, Huang W, Liu Z, et al
Phase 2 data showed participants losing up to 18.7% of body weight at the highest dose over 46 weeks
Their study, published in Annals of Internal Medicine , examined data from a large database of United States adults ages 18 to 65 with Type 2 diabetes who started taking medication to treat the condition, including glucagon-like peptide-1 receptor agonists, or GLP-1s
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