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doi: 10.1016/S0140-6736(12)60990-8 3 SeymourCWKennedyJNWangSChangCHElliottCFXuZet al

This promotes insulin secretion, improves insulin resistance, and inhibits lipogenesis which is associated with changes in the composition of the gut microbiota and its metabolites [( 3.1.1

In a 68-week clinical trial, patients treated with GLP-1 experienced an average weight loss of 14.9% from their initial body Trusted Source Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial Rubino D, Abrahamsson N, Davies M, et al Go to Source weight

Psychiatry 118:110580

A study of over 18,000 participants found that tirzepatide led to greater weight loss and improved blood sugar levels compared to semaglutide