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Expression of N 6 -trimethyllysine dioxygenase (TMLHE) which catalyzes the transformation of TML into hydroxy-N 6 -trimethyllysine (HTML) was not different between genotypes

58,59 Stav and Raz 55 found that treatment with NAC 1,200 mg for 6 weeks could increase exercise time, while in the HIACE 46 study, such improvement was not confirmed

Notably, an ongoing RCT investigating the effects of semaglutide on pre-treatment cognitive dysfunction in patients with major depression may provide useful insights in this regard (NCT04466345 (ref

This highlights the resolved corneal angiogenic privilege, a corneal avascular state known to be essential for cornea healing and transparency maintenance [122,123,124,125,126,127,128]