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Clinical trials have documented blood pressure reductions in semaglutide-treated patients that exceed what would be expected from weight loss alone

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Additionally, GIP directly stimulates lipogenesis, while GLP-1 indirectly promotes lipolysis, collectively maintaining healthy adipocytes, reducing ectopic fat distribution, and increasing the production and secretion of adiponectin from adipocytes

Patients with a history of gastroparesis, inflammatory bowel disease, and pancreatitis should also avoid GLP 1 RA given the potential risk of worsening side effects [46]