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These conflicting findings could be attributed to variations in the source of GPX3, whether derived primarily from the kidneys or locally expressed and secreted by bronchial epithelial cells

4 Probiotics and prebiotics as adjunctive therapeutic strategies in hypothyroidism The recognition of the gut-thyroid axis as a pivotal regulator of endocrine and immune homeostasis has spurred increasing interest in microbiota-targeted interventions for hypothyroidism

Cultures of Sertoli and Leydig cells from adult rats and immature pigs secrete immunoreactive IGF-I into the medium, and this secretion is enhanced by FSH (Sertoli cells) or LH (Leydig cells)[117, 118]

Balancing these different research perspectivesthe mechanistic optimism from preclinical science and the pragmatic constraints of clinical applicationis essential for future advancement

Torti SV, Torti FM