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Recently identification of an NO accrual mutant noe1 ( nitric oxide excess 1 ) in rice revealed that NOE1 encoded a rice catalase (CAT) OsCATC
AOD-9604, despite a safety database spanning six trials and around 900 participants, saw its early positive efficacy signal fail to replicate in its largest confirmatory trial meaning its safety data is well established
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This energy impairment likely results in a hypometabolic state as the illness progresses (59, 401, 407, 413), called the cell danger response (414416)
10.1016/j.ccr.2006.08.015 Cancer Cell 164 SenaL
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