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Thus, in a simplified model as shown in the following equation, the insulin secretion rate is determined by -cell glucose sensitivity and the blood glucose level, -cell GLP-1 sensitivity and the blood GLP-1 level, and -cell GIP sensitivity and the blood GIP level [7]

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Nowadays, LY3502790 and PF-06882961 (231233), a class of oral non-peptide small molecule GLP-1RAs with preferable efficacy and anti-diabetes potential, are at the stage of pre-clinical research

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Liu J., Aylor K.W., Liu Z