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Ferroptosis does not result in morphological changes similar to the chromatin condensation that occurs during apoptosis, the loss of plasma membrane integrity that occurs during necrosis, or the formation of double membranelayered autophagic vacuoles that occurs during autophagy

In murine models of breast cancer, ICIE significantly transformed the TME from immunologically cold to hot by diminishing immunosuppressive cells (Tregs, M2-TAMs, MDSCs), augmenting the infiltration of CTLs, and elevating the CD 8+ /Treg ratio

3.2 Combination Therapy The heterogeneity of cancer metabolism, even within the same tumor [62], poses many challenges for potential drug therapies

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DFP has been found to not only reduce the growth of some strains of common Gram-negative nosocomial pathogens, but also reduce the minimum inhibitory concentrations of antibiotics (Thompson et al., 2012)