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In addition, the biodegradable sodium alginate hydrogel S1P-PDL1@Ge which delivers sphingosine-1-phosphate (S1P) and anti-PD-L1 (PDL1), can significantly enhance the infiltration of DCs, M1 macrophages, CD4 + T cells and CD8 + T cells, effectively inhibit tumor growth and reduce local tumor recurrence (212)
It further suppressed the expression of cell-cycle-associated proteins, such as Ki67 and cyclin D1, resulting in inhibited tumor growth
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Each component consists of defined amino acid sequences associated with specific cellular signaling pathways
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