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"When it comes to IGF-1, I often see higher levels in those who sleep well and exercise regularly, but in contrast, I also see IGF-1 elevations associated with some medical conditions, including PCOS, insulin resistance, and cancer," Dr

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Because of its gastrointestinal side effects, Metformin should be started at a low dose with gradual titration, depending on tolerance

It also implies potential benefit of prehabilitation strategies (like exercise or nutritional supplements pre-surgery) that can boost mitochondrial function prior to the insult (72)