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1 Introduction Diabetic kidney disease (DKD) has recently become a global health threat and serves as one of the leading causes of chronic kidney disease and end-stage renal disease (Thomas et al., 2015)

The levels of antioxidant indicators, including superoxide dismutase, catalase, glutathione reductase, and nitric oxide, as well as peroxidation indicators such as myeloperoxidase and malondialdehyde, were measured using Enzyme-Linked Immunosorbent Assay (ELISA)

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NSAIDs like ibuprofen carry increased gastrointestinal risk when combined with semaglutide due to delayed stomach emptying and prolonged contact with stomach tissue

This is a solvable detective problem, but it stays unsolved when data are scattered and guesses pile up instead of testing one variable at a time