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Weight loss results vary significantly by specific medication and dose: Semaglutide 2.4 mg (Wegovy): Clinical trials (STEP program) showed average weight reductions of 1517% at 68 weeks Tirzepatide (Zepbound): SURMOUNT trials demonstrated weight reductions of 1522% at 72 weeks, with results varying between populations with and without diabetes Liraglutide 3 mg (Saxenda): Typically produces 510% weight loss over 56 weeks The rate of weight loss is not linear