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(2) RCTs completed before the FDA guidance of 2008 [17] and (3) follow-up duration of at least 6 months

Other Health Concerns with Energy Drinks In addition to increased kidney stones, energy drinks have other health impacts

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This NADPH is likely supplied by the activity of Ald6 an aldehyde dehydrogenase which has previously been shown to be critical in the absence of a functional pentose phosphate pathway (Grabowska and Chelstowska, 2003)

[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels