Acknowledgements This work was supported by the George Whipple Professorship, the National Natural Science Foundation of China (81902592, 82070785), Hunan Natural Science Foundation (2020JJ5884) and Hunan Province Young talents Program (2021RC3027)
However, for some patients, these effects can be persistent and troublesome enough to warrant dose reduction or discontinuation
While on the diet, the time needed for cholesterol crystals to form decreased in the placebo and ursodeoxycholic acid groups, but not in the omega-3 group, suggesting fish oil may prevent the increase in gallstone risk seen with low-calorie weight loss dieting (Mendez-Sanchez 2001)
Despite these advantages, the technology faces challenges such as high costs, limited yields, and the absence of bioactive and bio-functional enzymes necessary to produce stable and functional collagen [33, 34]
This proactive strategy can help establish new behavioral patterns while medication effects are still partially active