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This protein contains a RAS exchange motif, a diacylglycerol-binding C1 domain, two EF hand Ca 2+ -binding domains and a GEF domain

Competing interests None of authors currently have any financial interests or other relationships that might lead to conflict of interest

On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins

1c,d, and Supplementary Table 2) Characterizing four senolytic chloroacetamides Among the electrophilic compounds with senolytic activity identified, we concentrated on four senolytic chloroacetamides (SCLAs

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