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HFD mice showed mitochondrial swelling, and cristae disorganization

Cytosolic mtDNA acts as a ligand for cGAS, initiating a cascade via STING that culminates in production of type I interferons, IL-6, and other pro-inflammatory cytokines

Reducing the consumption of foods that are high in phosphorus (phosphate), such as meat, poultry, fish, dairy products, chocolate, beans, lentils, nuts, some whole grains, baking powder, and soft drinks (especially colas and other dark-colored sodas), becomes increasingly important as kidney function declines

ERO1A is a FAD-dependent enzyme catalyzing the oxidative folding (formation of disulfide bonds) of secretary proteins in the ER 42,43