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Beyond their primary role in improving glycemic control in patients with T2DM, DPP-4 inhibitors also demonstrate different effects on bone metabolism [107], e.g

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In subgroup analyses based on the drugs used in the control arms, the overall cancer risks were identical in the tirzepatide group compared to the placebo, insulin, and GLP-1RA groups

Future research incorporating validated biomarkers of biological aging, functional outcomes, and long-term disease risk will clarify their role more precisely