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Meta-analyses have confirmed that GLP-1 receptor agonists reduce cardiovascular risk while producing only minor elevations in resting heart rate

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Sinoatrial node chronotropy direct Gs/cAMP signaling via GLP-1R at the hearts pacemaker, running through the pacemaker cells sarcoplasmic-reticulum calcium clock (phospholamban Ser16 and ryanodine-receptor phosphorylation), not the funny current

Although a causal association with acute pancreatitis remains debated, observational studies suggest a higher incidence compared with placebo (Nieto et al., 2025