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Eur Heart J 1994;15:1267-73
SLC22A12 produces a genetic variation that contributes to urate absorption and is a key factor in hyperuricaemia and gout (Toyoda et al., 2015
What the data shows: REDEFINE-1 (obesity without diabetes): 22.7% average weight loss vs 2.3% placebo | 91.9% achieved 5% weight loss REDEFINE-2 (type 2 diabetes + obesity): 14-16% weight loss sustained over 68 weeks Consistent GLP-1 class safety profile with potential for fewer GI side effects due to amylin co-agonism What this means for practice: This isn't just another weight-loss drugit's addressing the mechanistic gap in dual-pathway therapy
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The fatigue was so severe that I was literally sleeping in my office between patient appointments, Seltzer tells Runners World
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