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If these toxic byproducts build up, they can halt energy production entirely

As well as when patients with -thal were exogenously supplemented with vitamin E, researchers found that antioxidants could mitigate oxidative stress in erythrocytes through multiple targets, thereby impacting iron overload ( On the other hand, iron overload may also be an intermediate link in the interaction between ferroptosis and, IE in -thal

Mukamel et al., 2011)