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The study included patients with HbA1c levels ranging from 7.0-10.0% (53-86 mmol/mol) who were being treated with diet and exercise with or without metformin

Retatrutide Dosage: Clinical Trial Evidence and Established Regimens Phase 1 Trials: Dose-Ranging and Tolerability Initial retatrutide dosage exploration established safety and pharmacokinetic parameters: Phase 1 conclusion : The retatrutide dosage range of 1-12 mg weekly demonstrated dose-dependent efficacy and tolerability, with 6-9 mg emerging as the likely therapeutic sweet spot

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In addition, hyperinsulinemia is responsible for the increase in the androgen production through both the direct stimulation of insulin receptors and the cross-reaction with Insulin-like Growth Factor-1 (IGF-1) receptors expressed on thecal cells [14]

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