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Additionally, the secondary bile acids 3-oxoLCA and isoLCA function as TGR5 agonists that suppress the differentiation of Th17 cells in vitro through two mechanisms: (1) directly inhibiting the expression of RORt, and (2) promoting the polarization of M2 macrophages, which indirectly inhibits the development of Th17 cells (119)

However, no effect of selenium supplementation on thyroid stimulating hormone, health-related quality of life or thyroid ultrasound was found in levothyroxine substitution-untreated individuals, and sporadic evaluation of clinically relevant outcomes in levothyroxine substitution-treated patients (108.5)

10.1016/j.exer.2018.10.009 40 HeG

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