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The level of oxidized glutathione (GSSG) was significantly decreased by 22% after Pycnogenol administration, while reduced glutathione (GSH) was significantly increased by 26.8% after one month and by 36.4% after 2 months compared to baseline (35)

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10.1111/jcmm.13920 122 WangD.LippardS

In this context, disruption of temporal coordination, rather than hormone abundance alone, may limit effective engagement of melatonin-dependent immunoregulatory pathways