explain glp 1 Understanding semaglutide (GLP-1 RA): Are they the right choice for weight loss? How Does Ozempic Work? GLP-1

Ferringer, MD, FAAD, Chair Khalid Ali Al Hawsawi, MD Neal D

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As the GLP-1R is not expressed on human hepatocytes, the GLP-1RA-mediated effects on fatty liver are probably indirectly mediated through GLP-1RA-induced weight loss and ensuing improvement in insulin resistance, and, potentially, anti-inflammatory effects associated with GLP-1RA treatment (29)