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When the Ipamorelin-preexposed pituitary cells were later cultured and challenged in vitro with the endogenous hormone GHRH, the Ipamorelin-primed group appeared to exert a clear increase in both the proportion of GH-immunostained somatotrophs and their intracellular growth hormone content

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This ranks it the lowest of the three compared methods, but despite this, it may be the most preferable option for some

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The 2mg starting dose was well tolerated in the trial, with gastrointestinal effects -- nausea, diarrhea -- most common at higher doses