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It is a stress-inducible protein and protects the cells by regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation

Biochem Biophys Res Commun 497:207213

Cureus 10 , e3297 (2018)

APP cleavage in the amyloidogenic pathway is a critical step in the generation of A peptides, which accumulate in the brains of individuals with AD (Chen et al., 2009