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Lixisenatide and renal outcomes in patients with type 2 diabetes and acute coronary syndrome: an exploratory analysis of the ELIXA randomised, placebo-controlled trial

Compared to chow feeding, high-fat feeding for 35 weeks resulted in substantial rearrangement of the gut microbiota reflected by reduced bacterial community richness and diversity accompanied by highly consistent changes in the abundance of major bacterial divisions, dominated by phylum-level taxonomic shifts in Firmicutes , Bacteroidetes , Proteobacteria and Actinobacteria

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However, further investigations are warranted to decipher the complete mechanism underlying the protective effect of GLP1R agonists against hepatic steatosis