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The most detailed population-level analysis comes from Wharton et al., published in Diabetes, Obesity and Metabolism in 2021, which pooled data from the STEP 13 trials

The first step (for all OA patients) is following an anti-inflammatory diet (mainly the MD, rich in -3 PUFAs, fruits, vegetables, and whole grains), combined with weight loss of 510% (for those with a BMI 25) and low-impact exercises (such as swimming) for 3 months

It is not medical advice.

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