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Then the reactor contents are cooled to about -10 (-13 to 0) and a solution of diethyl p -toluenesulfonyloxymethylphosphonate (2.25 kg on a pure basis) in DMF (1.22 kg) is added over about 5-10 hours

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These findings align with observational links between higher follicular-fluid melatonin and better oocyte/embryo metrics, supporting a mechanistic redoxmitochondrial pathway

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