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MLM production in 5 L fermentation To achieve higher MLM production, the recombinant was cultivated in optimized media containing 20 g/L glucose, 5 g/L (NH 4 ) 2 SO 4 , 1.7 g/L YNB, dropout-Leu supplement 1.29 g/L, and 0.5 g/L glutamate

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The interplay between CoQ redox balance, AMPK activation and ETC directionality suggests that the ferroptotic outcome of complex I inhibition depends not only on its biochemical activity but also on the metabolic state of the cell

Conclusions Our results strongly suggest that oral GSH supplementation replenishes the bodys stores of GSH and significantly reduces oxidative DNA damage in Indian T2D patients

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