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In addition to generating antibodies, Mojsov needed to devise a chromatographic method to detect GLP-1 (7-37) and separate it from other relevant peptides (Barany, Barany)
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Knock out of the enzyme protein-tyrosine phosphatase 1B (PTP-1B) that is , responsible for inhibiting leptin and insulin signaling in the hypothalamus and other brain areas resulted in animals gaining less weight when fed a high-calorie diet than did normal controls (23.)
It also slows gastric emptying, which keeps food in your stomach longer than usual
Am J Physiol Regul Integr Comp Physiol 311: R124-132, 2016
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